Safari
Safari: About Internet plug-in management
Safari 6.1 and later allow you to enable or disable Internet plug-ins on a website-by-website basis.

Safari: "Manage Website Settings…" lets you enable the Java web plug-in website-by-website
In Safari versions 5.1.9, 5.1.10, 6.0.4, and 6.0.5, you can enable the Java web plug-in on a website-by-website basis, with four settings to choose from.

Safari blocks content on some non-standard ports
Website administrators may notice that Safari will block requests for HTTP, HTTPS and other content on some nonstandard ports. Requests involving invalid port numbers (for example, port 0 or port numbers at or above 49152) will also be blocked. When … Continue reading
Safari 5.1, Safari 6: Unable to access websites via web proxy
After installing Mountain Lion (which includes Safari 6), or installing Safari 5.1 or Safari 6 in OS X Lion, you may not be able to access websites via a web proxy (HTTP) that uses a file-based Proxy Automatic Configuration (PAC) file.

OS X Lion v10.7.3: Safari opens empty page when using Speakable Items to go to a webpage
When using Speakable Items to go to a webpage in Safari (after using the command “Make this page speakable”), Safari may open an empty page.
Unsupported third-party add-ons may cause Safari to unexpectedly quit or have performance issues
Unsupported Safari Add Ons installed as Input Methods, Input Managers, or Scripting Additions might cause Safari to unexpectedly quit or have performance issues.

Mac Basics: Safari 6 in OS X Mountain Lion
Learn about using Safari 6 in Mountain Lion, as well as ways to personalize your browsing experience.
Mac Basics: Browse the web with Safari 7 in Mavericks
Safari is the web browser included with OS X Mavericks. Learn about using Safari, as well as ways to personalize your browsing experience.